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Fig. 2 | Chinese Medicine

Fig. 2

From: Weight changes in hypertensive patients with phlegm-dampness syndrome: an integrated proteomics and metabolomics approach

Fig. 2

Biological network and canonical pathways related to the identified proteins in Hypertensive Patients with Phlegm-Dampness Syndrome. A Ingenuity Pathway Analysis (IPA)-identified H–N/N–H proteins network. The N–H BMI was considered 18.5 ≤ BMI < 24 kg/m2 initially and BMI ≥ 24 kg/m2 next year), and H-N BMI was defined as the BMI at the first health check-up greater than or equal to 24 kg/m2 and 18.5 ≤ BMI < 24 kg/m2 next year, according to the Chinese Obesity Working Group and World Health Organization categorization. Molecules in the network are represented as nodes, and the biological relationship between two nodes is represented as a line. The coloured symbols represent the metabolites, proteins and pathways that occurred in the findings, while the transparent entries are molecules from the Ingenuity Knowledge Database. Red symbols represent up-regulated metabolites or proteins, the light red symbols represent the modestly up-regulated metabolites/proteins, green symbols represent down-regulated metabolites/proteins, and the light green symbols represent the modestly down-regulated metabolites/proteins. Solid lines between molecules indicate a direct physical relationship between the molecules, while dotted lines indicate indirect functional relationships. B IPA identified pathway: LXR/RXR activation, FXR/RXR activation, acute phase response signalling and the complement system. The Y-axis represents the top functions as calculated by IPA based on differentially expressed genes are highlighted and the X-axis represents the ratio of the number of genes from the dataset that map to the pathway and the number of all known genes ascribed to the pathway. The orange threshold line marks the p = 0.05. The threshold of p-value < 0.05 as calculated by Fischer's test. C IPA identified most highly rated network. The network representation of the most highly rated network. Complement C3, Complement C4a/C4b, Alpha-2-macroglobulin (A2M), Serpin family F member 1 (SERPINF1) that are shaded were determined to be significant from the statistical analysis. These proteins shaded dark blue are upregulated and those that are light blue are downregulated. A solid line represents a direct interaction between the two proteins

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