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Fig. 6 | Chinese Medicine

Fig. 6

From: Global trends and prospects about inflammasomes in stroke: a bibliometric analysis

Fig. 6

Summary of main literature. A Ischemic stroke (including CVT, GCI, FCI and NHIBD) and hemorrhagic stroke (including SAH and ICH) are major types of stroke. The full name is marked in the "abbreviations" section. B DAMPs and PAMPs lead to dysregulation of extracellular pH, efflux of Ca2+, failure of K+/Na+ ATPases, mitochondrial dysfunction, and DNA damage, which further more result in inflammasomes are activated. C Inflammasomes in general are expressed in microglia, astrocytes, neurons, and endothelial cells. Activation of inflammasomes releases excessive inflammatory cytokines, including IL-1β, IL-18, IL-6 and TNF-α, and finally contributes to cell death

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