Fig. 2

The neuroprotective effects of CSBTA in the PIPN model. A In the first week, 2 mg/kg paclitaxel was injected intraperitoneally every other day. Vehicle or CSBTA (30 mg/kg or 120 mg/kg) were oral administrator before paclitaxel treatment. B Mean body weight during the experimental period. C The Von Frey filament test was used to detect the change of mechanical allodynia in rats. The lower the value, the higher the sensitivity of the animal to mechanical stimulation. D Drikold simulation experiment was used to detect cold hyperalgesia. The lower the value, the higher the sensitivity of animals to cold. E, F Laser heat tingling and tail immersion test were used to detect the sensitivity of rats to a thermal stimulus. The results were presented as means ± SD from 8 rats in each group, n = 8. ^##p < 0.01, ^#p < 0.05 compared with the blank group; *p < 0.05, **p < 0.01 compared with paclitaxel model group