The toxicology and detoxification of Aconitum: traditional and modern views

Chinese Medicine

Table 2 Toxic dose and LD₅₀ of the herbs and compounds in Aconitums

Herb/Compound	Species	p.o	s.c	i.p	i.v	Ref
Raw Chuanwu	Mouse	18,000 mg/kg				[127]
Aconitine	Mouse	1.8 mg/kg	0.24–0.31 mg/kg	0.28–0.34 mg/kg	0.12 mg/kg	[69]
	Mouse		0.55 mg/kg			[128]
	Rat				0.102 mg/kg	[127]
	Rat				0.112 mg/kg	[103]
	Cat				0.07–0.13 mg/kg
	Dog				0.5 mg/kg
	Human	2-5 mg				[127]
Mesaconitine	Mouse	1.9 mg/kg	0.19–0.22 mg/kg	0.20–0.23 mg/kg	0.10 mg/kg	[69]
	Mouse		0.25 mg/kg			[128]
	Mouse				0.068 mg/kg	[129]
	Rat				0.158 mg/kg	[103]
Hypaconitine	Mouse	5.8 mg/kg	1.1–1.3 mg/kg	1.0–1.2 mg/kg	0.47 mg/kg	[69]
	Mouse		1.9 mg/kg			[128]
	Rat				0.291 mg/kg	[103]
Benzoylaconitine	Mouse			70 mg/kg	23 mg/kg	[69]
	Rat				> 20.2 mg/kg	[103]
Benzoylmesaconine	Mouse	810 mg/kg	230 mg/kg	240 mg/kg	21 mg/kg	[69]
	Rat				> 18.7 mg/kg	[103]
Benzoylhypaconine	Mouse	830 mg/kg	130 mg/kg	120 mg/kg	23 mg/kg	[69]
	Rat				> 20.4 mg/kg	[103]
Lappaconitine	Mouse				5.9 ~ 11.5 mg/kg	[124]
Jesaconitine	Mouse		0.23 mg/kg			[128]
Songorine	Mouse				106 mg/kg	[129]
Heteratisine	Mouse				147 mg/kg	[129]
Napelline	Mouse				> 147 mg/kg	[129]

ISSN: 1749-8546