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Fig. 4 | Chinese Medicine

Fig. 4

From: Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2

Fig. 4

PTE inhibits TGF-β1-induced EMT and ECM accumulation by downregulating ASIC2. A549 and AECs that were transfected with ASIC2 overexpression plasmid were treated with 10 ng/ml TGF-β1 and 30 μmol/L PTE for 24 h. The expressions of ASIC2 (A, B), key protein of EMT (C, D), α-SMA, and ECM (E, F) were detected by western blot. All experiments were repeated 3 times independently, and Student’s t test or ANOVA was used to compare the differences between groups. *P < 0.05 compared with TGF-β1 group; #P < 0.05 compared with TGF-β1 + PTE group

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