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Table 2 Potential targets of GQWTF against T2DM

From: Mechanism exploration of Gouqi-wentang formula against type 2 diabetes mellitus by phytochemistry and network pharmacology-based analysis and biological validation

No Protein name Gene symbol Uniprot ID
1 Bile acid receptor NR1H4 Q96RI1
2 Caspase-1 CASP1 P29466
3 Cytochrome P450 2C8 CYP2C8 P10632
4 Cytochrome P450 2C9 CYP2C9 P11712
5 Hexokinase-4 GCK P35557
6 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B Q07343
7 Glucocorticoid receptor NR3C1 P04150
8 Neprilysin MME P08473
9 Albumin ALB P02768
10 Peroxisome proliferator-activated receptor alpha PPARA Q07869
11 Renin REN P00797
12 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial PDK2 Q15119
13 Nuclear receptor subfamily 1 group I member 3 NR1I3 Q14994
14 Peroxisome proliferator-activated receptor delta PPARD Q03181
15 Mitogen-activated protein kinase 8 MAPK8 P45983
16 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 P18031
17 Integrin alpha-L ITGAL P20701
18 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR P04035
19 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D Q08499
20 Dipeptidyl peptidase 4 DPP4 P27487
21 Poly [ADP-ribose] polymerase 1 PARP1 P09874
22 Mineralocorticoid receptor NR3C2 P08235
23 Insulin-like growth factor 1 receptor IGF1R P08069
24 3-phosphoinositide-dependent protein kinase 1 PDPK1 O15530
25 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 P28845
26 Fibroblast growth factor receptor 1 FGFR1 P11362
27 Retinoic acid receptor RXR-alpha RXRA P19793
28 Amine oxidase [flavin-containing] B MAOB P27338
29 Insulin receptor INSR P06213
30 Mitogen-activated protein kinase 10 MAPK10 P53779
31 Peroxisome proliferator-activated receptor gamma PPARG P37231
32 Carbonic anhydrase 2 CA2 P00918
33 Retinoic acid receptor RXR-beta RXRB P28702
34 Prothrombin F2 P00734
35 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG P48736
36 Carbonic anhydrase 1 CA1 P00915
37 Alpha-amylase 1C AMY1C P0DTE8
38 Alpha-amylase 1A AMY1A P0DUB6
39 Alpha-amylase 1B AMY1B P0DTE7