Table 2 Potential targets of GQWTF against T2DM

1

Bile acid receptor

NR1H4

Q96RI1

2

Caspase-1

CASP1

P29466

3

Cytochrome P450 2C8

CYP2C8

P10632

4

Cytochrome P450 2C9

CYP2C9

P11712

5

Hexokinase-4

GCK

P35557

6

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

PDE4B

Q07343

7

Glucocorticoid receptor

NR3C1

P04150

8

Neprilysin

MME

P08473

9

Albumin

ALB

P02768

10

Peroxisome proliferator-activated receptor alpha

PPARA

Q07869

11

Renin

REN

P00797

12

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

PDK2

Q15119

13

Nuclear receptor subfamily 1 group I member 3

NR1I3

Q14994

14

Peroxisome proliferator-activated receptor delta

PPARD

Q03181

15

Mitogen-activated protein kinase 8

MAPK8

P45983

16

Tyrosine-protein phosphatase non-receptor type 1

PTPN1

P18031

17

Integrin alpha-L

ITGAL

P20701

18

3-hydroxy-3-methylglutaryl-coenzyme A reductase

HMGCR

P04035

19

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

PDE4D

Q08499

20

Dipeptidyl peptidase 4

DPP4

P27487

21

Poly [ADP-ribose] polymerase 1

PARP1

P09874

22

Mineralocorticoid receptor

NR3C2

P08235

23

Insulin-like growth factor 1 receptor

IGF1R

P08069

24

3-phosphoinositide-dependent protein kinase 1

PDPK1

O15530

25

Corticosteroid 11-beta-dehydrogenase isozyme 1

HSD11B1

P28845

26

Fibroblast growth factor receptor 1

FGFR1

P11362

27

Retinoic acid receptor RXR-alpha

RXRA

P19793

28

Amine oxidase [flavin-containing] B

MAOB

P27338

29

Insulin receptor

INSR

P06213

30

Mitogen-activated protein kinase 10

MAPK10

P53779

31

Peroxisome proliferator-activated receptor gamma

PPARG

P37231

32

Carbonic anhydrase 2

CA2

P00918

33

Retinoic acid receptor RXR-beta

RXRB

P28702

34

Prothrombin

F2

P00734

35

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PIK3CG

P48736

36

Carbonic anhydrase 1

CA1

P00915

37

Alpha-amylase 1C

AMY1C

P0DTE8

38

Alpha-amylase 1A

AMY1A

P0DUB6

39

Alpha-amylase 1B

AMY1B

P0DTE7