Fig. 5

Effects of 3,3′4,5′-TMS and 3,4′,5-TMS on MAPK signaling pathway. The cells were pretreated with 3,3′,4,5′-TMS or 3,4’,5-TMS (10 and 50 µM) for 4 h and then co-treated with LPS (1 µg/mL) for 12 h. a, b Representative blots and summarized data showing the effects of c–e 3,3′4,5′-TMS and f–h 3,4′,5-TMS on the phosphorylation of P38 at Thr180/Tyr182, JNK at Thr183/Tyr185, and ERK at Thr202/Tyr204 normalized to its respective total protein. Data are expressed as the mean ± SEM, n = 3–4. ^#P < 0.05 vs control. *P < 0.05 vs LPS