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Fig. 6 | Chinese Medicine

Fig. 6

From: Two methoxy derivatives of resveratrol, 3,3′,4,5′-tetramethoxy-trans-stilbene and 3,4′,5-trimethoxy-trans-stilbene, suppress lipopolysaccharide-induced inflammation through inactivation of MAPK and NF-κB pathways in RAW 264.7 cells

Fig. 6

Effects of 3,3′4,5′-TMS and 3,4′,5-TMS on NF-κB signaling pathway. The cells were pretreated with 3,3′,4,5′-TMS or 3,4′,5-TMS (10 and 50 µM) followed by LPS incubation (1 µg/mL) for 12 h. a Representative blots and summarized data showing the effect of 3,3′4,5′-TMS on the phosphorylation of b IKKα/β at Ser176/180, c IκBα at Ser32, and d P65 at Ser536, as well as e SIRT1 expression as compared to its respective total protein or GAPDH. f Representative blots and g–j summarized data showing the effects of 3,4′,5-TMS. Data are expressed as the mean ± SEM, n = 3–4. #P < 0.05 vs control. *P < 0.05 vs LPS

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