Skip to main content
Fig. 5 | Chinese Medicine

Fig. 5

From: Chaihu-Shugan-San (Shihosogansan) alleviates restraint stress-generated anxiety and depression in mice by regulating NF-κB-mediated BDNF expression through the modulation of gut microbiota

Fig. 5

Fecal transplantations of normal control and CSS/RS-treated mice alleviated restraint stress (RS)-induced anxiety and depression in the transplanted mice. Effects on RS-induced anxiety/depression-like behaviors in the EPM task (A: a, time spent in open arm [OT]; b, open arm entries [OE]), LDT (B; a, time spent in the light box [TL]; b, number of transition into the light box entry [NT]), TST (C), and FST (D). Effects on IL-6 (E) and NF-κB activation (p-p65 to p65 ratio) (F) in the hippocampus. Effect on corticosterone (G) and IL-6 (H) in the blood. RS, IFC, and IFN groups were treated with vehicle (saline), fecal microbiota of CSS/RS-treated mice (FC), and fecal microbiota of normal control mice (FN) in mice with RS-induced depression daily for 5 days from 24 h after the exposure to RS, respectively. NC group was orally treated with vehicle (saline) in normal control mice instead of the fecal sample. Data values were indicated as mean ± SD (n = 6). #p < 0.05 vs. Con group. *p < 0.05 vs. RS group

Back to article page

Chinese Medicine

ISSN: 1749-8546

Contact us