Fig. 2From: Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytesSKN reduces the inflammatory cells density in the synovium of inflamed joints in collagen-induced arthritis (CIA) mice. A, C HE staining photomicrographs of synovium from knee joints of normal control, CIA, SKN (4 mg/kg)-treated CIA mice and MTX (0.5 mg/kg)-treated CIA mice, respectively. B, D Vimentin immunofluorescence staining images of synovium from knee joints of normal control, CIA, SKN (4 mg/kg)-treated and MTX (0.5 mg/kg)-treated CIA mice are shown, respectively. Data is expressed as an average ± SEM (n = 6). ###p < 0.001, compared to the control group; *P < 0.05, **P < 0.01, and ***P < 0.001, relative to the CIA groupBack to article page