Fig.6

SKN might interact with SOCS1. A The homology model of SOCS1. B Ramachandran plot for SOCS1. Dark green dots represent the residues in favored regions; yellow dots represent the residues in allowed regions, red cross represent the residues in irrational regions. C The structure-based sequence comparison between SOCS1 and the template structure. The mismatched residues are displayed with fade, the sequence corresponding to alpha-helix and beta strand regions are marked with blue and green color. D The 2D binding mode of SOCS1 and SKN. E The binding model of SKN on molecular surface of SOCS1. SKN is colored in cyan, the molecular surface of SOCS1 is colored in pale yellow. F The 3D binding mode of SOCS1 and SKN. SKN is colored in cyan, the surrounding residues in the binding pockets are colored in yellow, the backbone of the receptor is depicted as white cartoon with transparency