Fig. 5

a, b Effects of LHQW and LHQK on the expression of IRF, TCIRG1 in peripheral blood of HCoV-229E-infected mice at 48 h and D8 after viral challenge. Data are presented as Mean ± SD (n = 10 in each group). ⁺P ≤ 0.05, ⁺⁺P ≤ 0.01 vs normal group. *P ≤ 0.05, **P ≤ 0.01 vs model group. c, d Effects of LHQW and LHQK on the expression of IL-2, IL-6, IL-8, IL-12 and TNF-α in lung tissue of infected mice at 48 and D8 after viral challenge. Data are presented as Mean ± SD (n = 8 in each group). ⁺P ≤ 0.05, ⁺⁺P ≤ 0.01 vs normal group. *P ≤ 0.05, **P ≤ 0.01 vs model group