Fig. 2

The mechanism of TMAO affecting CHD. Cyp7a1 cholesterol 7α-hydroxylase, SR-A1 scavenger receptor A1, NLRP3 pyrin domain-containing-3, TMA trimethylamine, FMO3 flavin-containing monooxygenase 3, TMAO trimethylamine N-oxide, TXNIP thioredoxin binding protein, ROS reactive oxygen species, NF-kB nuclear factor-kappa B, MAPK mitogen-activated protein kinase, TNF-α tumor necrosis factor-α, IL-6 interleukin 6, IL-1β interleukin-1 beta