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Fig. 3 | Chinese Medicine

Fig. 3

From: Scutellarin ameliorates neonatal hypoxic-ischemic encephalopathy associated with GAP43-dependent signaling pathway

Fig. 3

The impact of GAP43 silencing on the therapeutic efficacy of Scu treatment. a Light field images of neurons in the Control, Normal, Scu + NC, Scu + GAP43-si, OGD, OGD + Scu + NC, OGD + Scu + GAP43-si groups. b Morphological changes of neurons in the normal, OGD, OGD + Scu + GAP43-si, OGD + Scu + NC groups by TUNEL/DAPI staining. c Immunostaining of Tuj1 cells in the former 4 groups. d Cell number comparison among the normal, Scu + NC, Scu + GAP43-si groups. e Average length changes of neurites in aforementioned three groups. f Cell number comparison in the normal, OGD, OGD + Scu + NC, OGD + Scu + GAP43-si groups. g Average length changes of neurites among four groups above. h TUNEL/DAPI staining results in the normal, OGD, OGD + Scu + NC, OGD + Scu + GAP43-si groups. OGD Oxygen–glucose deprivation, Scu Scutellarin, NC negative control, GAP43-si GAP43 silencing. *p < 0.05, scale bar = 50 μm, n = 3/group

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Chinese Medicine

ISSN: 1749-8546

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