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Table 1 MIC values of colistin alone or in combination with Pingwei Pill (1.024 mg/mL) in various tested strains. Data are presented as the means ± S.D (n = 3)

From: NMPA-approved traditional Chinese medicine-Pingwei Pill: new indication for colistin recovery against MCR-positive bacteria infection

Species

mcr-1 confirmation

Antibiotics

MIC (µg/mL)

Alone

Combination

FIC Index

E. coli ATCC 25,922

–

Colistin

1.50 ± 0.58

1.06 ± 0.18

1.06 ± 0.16

K. pneumoniae ZJ02

+

Colistin

48 ± 18.48

2.0 ± 0.00

0.11 ± 0.12

Cephalothin sodium

1024.00 ± 0.00

853.33 ± 295.60

1.08 ± 0.29

Penicillin

853.3 ± 295.60

1024 ± 0.00

1.08 ± 0.29

meropenem

0.50 ± 0.00

0.50 ± 0.00

1.08 ± 0.29

Streptomycin

682.67 ± 295.60

512 ± 0.00

1.25 ± 0.00

Kanamycin

512.00 ± 0.00

426.67 ± 147.80

1.08 ± 0.29

Gentamycin

853.33 ± 295.60

853.33 ± 295.60

1.25 ± 0.00

Chloramphenicol

682.67 ± 295.60

682.67 ± 295.60

1.25 ± 0.00

Erythromycin

256.00 ± 0.00

170.67 ± 73.90

0.92 ± 0.29

Acheomycin

341.33 ± 147.80

213.33 ± 73.90

0.92 ± 0.29

Ciprofloxacin

426.67 ± 147.80

384 ± 221.70

1.08 ± 0.29

Salmonella sp. strain HYM2

+

Colistin

21.33 ± 9.24

1.33 ± 0.58

0.07 ± 0.05

Cephalothin sodium

42.67 ± 18.48

32.00 ± 0.00

0.84 ± 0.29

Penicillin

21.33 ± 9.24

21.33 ± 9.24

1.00 ± 0.00

meropenem

0.10 ± 0.04

0.08 ± 0.04

0.83 ± 0.29

Streptomycin

341.33 ± 147.80

213.33 ± 73.90

0.72 ± 0.30

Kanamycin

682.67 ± 295.60

426.67 ± 147.80

0.77 ± 0.31

Gentamycin

853.33 ± 295.60

682.67 ± 295.60

1.00 ± 0.33

Chloramphenicol

426.67 ± 147.80

256.00 ± 0.00

0.73 ± 0.29

Erythromycin

213.33 ± 73.90

170.67 ± 73.90

0.875 ± 0.30

Acheomycin

512 ± 0.00

341.33 ± 147.80

0.75 ± 0.32

Ciprofloxacin

6.67 ± 2.31

5.33 ± 2.31

0.83 ± 0.29

E. coli DH5α (pUC19-mcr-1)

+

Colistin

10.67 ± 4.62

2.00 ± 0.00

0.21 ± 0.072

E. coli ZJ478

+

Colistin

13.33 ± 4.62

2.00 ± 0.00

0.17 ± 0.07

E. coli ZJ40

+

Colistin

53.33 ± 18.48

2.67 ± 1.15

0.05 ± 0.02

Salmonella GP9

–

Colistin

26.67 ± 9.24

21.33 ± 9.24

1.08 ± 0.29

Salmonella ZZW20 (mcr-8 positive)

+

Colistin

42.67 ± 18.48

10.67 ± 4.62

0.29 ± 0.19

Salmonella sp. strain 15E464 (mcr-3 positive)

+

Colistin

53.33 ± 18.48

5.33 ± 2.31

0.10 ± 0.04

  1. Boldface indicates a synergistic effect with an FICI less than 0.5