Fig. 1

Total ion chromatogram of LBRD standard decoction in positive and negative ion mode using UHPLC-Q-TOF/MS. The samples were analyzed in positive (A) and negative (B) modes, ranging from m/z 50–1500. The UHPLC-Q-TOF/MS information of all the compounds were obtained and the data were processed using Thermo Xcalibur 3.0 software. Elements in use (C 0–40, H 0–80, O 0–30, and Na 0–1) and mass tolerance (< 5 ppm for diterpenes, lactones, and flavonoids, and < 10 ppm for phenolic acids) were set accordingly to narrow down the options for molecular analysis