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Fig. 6 | Chinese Medicine

Fig. 6

From: Integrated analysis of the chemical-material basis and molecular mechanisms for the classic herbal formula of Lily Bulb and Rehmannia Decoction in alleviating depression

Fig. 6

LBRD standard decoction protects PC12 cells against CORT-induced injury. A PC12 cells were exposed to CORT (200 and 400 μM) CORT for 24 h and then with LBRD standard decoction-containing serum (5%, 10%, and 20%). Cell viability was determined by CCK-8 assay (n = 6). Quantification of monoamine neurotransmitters 5-HT (B), NE (C), GABA (D), Glu (E) and inflammatory cytokine IL-1β (F), TNF-α (G), IL-6 (H) and IL-10 (I), in cell culture supernatant (n = 6) harvested from 200 μM CORT-induced PC12 cell depression model intervened with LBRD standard decoction. Data are presented as mean ± SEM and differences between two groups were compared by Student’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001, compared to the vehicle; #P < 0.01, ##P < 0.01, ###P < 0.001, compared to the CORT group

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