Fig. 7

The miRNA/mRNA regulatory network of LBRD standard decoction-containing serum treatment for CORT-induced PC12 cell depression model. A Heat map of differentially expressed miRNAs in each PC12 group (n = 3). B Heat map of differentially expressed mRNAs in each PC12 group (n = 3). Java Tree View were applied to generate a list of genes based on thermograph to visualize the gene expression profiles in each group. The color changes from red to blue corresponding to expression level changes from high to low, respectively. C, D Interactive network of miRNA/mRNA for LBRD standard decoction treatment for CORT-induced PC12 cell depression model. Blue represents down-regulated miRNAs and up-regulated mRNAs from the LBRD standard decoction-containing serum in comparison to the CORT group, as well as the CORT-treated cells compared to vehicle cells. Red represents up-regulated miRNAs and down-regulated mRNAs. E KEGG pathway of those predicted target mRNAs overlapped with DEGs from transcriptome data about LBRD standard decoction-containing serum treatment for CORT-induced PC12 cell depression model