Fig. 9

Schematic diagram of integrated analysis of the chemical-material basis and miRNA/mRNA regulatory network for LBRD standard decoction alleviating depression. The nervous, immuno-inflammatory, and endocrine systems were mainly involved in the antidepressant mechanisms of the LBRD standard decoction. Notably, LBRD standard decoction changed a series of miRNAs by which targeted mRNAs correlated to GABAergic synapse, RAS, circadian rhythm and neurotrophic signaling pathways to achieve a homeostatic state of multi-system functions in depression