Exploring biological basis of Syndrome differentiation in coronary heart disease patients with two distinct Syndromes by integrated multi-omics and network pharmacology strategy

Table 4 Disease clusters enriched with Syndrome-specific genes in the metabolite-gene networks

Syndrome	Enrichment score/Rank	Disease Term	P value	Mapped genes
CCQS	3.09/1	Metabolic syndrome	5.28E−05	MMP1, PON1, ADIPOQ, HMOX1, F3
		Atherosclerosis, coronary	0.001006	MMP1, PON1, ADIPOQ, HMOX1
		Atherosclerosis	0.010393	MMP1, PON1, ADIPOQ, HMOX1
QSBS	2.58/1	Hyperlipidemias	7.44E−04	SREBF1, APOA1, APOE
		Hypercholesterolemia	9.77E−04	SREBF1, APOA1, APOE
		Plasma HDL cholesterol (HDL-C) levels	0.024904	SREBF1, APOA1, APOE
	2.41/2	Cerebrovascular disease; sickle cell anemia	2.12E−04	APOA1, APOE, ICAM1
		Coronary Artery Disease	0.001195	APOA1, APOE, ICAM1
		Acute Coronary Syndrome	0.002469	APOA1, APOE, ICAM1
		Hepatitis C\|Remission, Spontaneous	0.005417	APOA1, APOE, ICAM1
		Atherosclerosis, coronary	0.010151	APOA1, APOE, ICAM1
		Stroke	0.100306	APOA1, APOE, ICAM1

ISSN: 1749-8546