Fig. 11
Expression of indicators of bone metabolism in rat cartilage tissue as determined by RT-qPCR. Drugs were administered via the oral route, and methotrexate (MTX) was used as a positive control (0.3 mg/kg, administered once daily). EF was administered at 2 g kg−1 day−1 (EF-L) and 4 g kg−1 day−1 (EF-H). Data are the mean ± SD (n = 6), *p < 0.05, **p < 0.01, ***p < 0.001, vs. CIA rats without treatment by EF or MTX, #p < 0.05, ##p < 0.01, ###p < 0.001, vs. normal group