From: Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity
Toxicity | Animals | Administration route | Minimum toxic dose | References |
---|---|---|---|---|
Hepatotoxicity | Female Wistar rats | Oral gavage | 1Â mg/kg/day, 14 days | [86] |
 | Male BALB/C mice | Intraperitoneal injection | 1 mg/kg, 24 h | [87] |
 | Female SD rats | Oral gavage | 0.4 mg/kg/day, 28 days | |
 | Female C57BL/6 mice | Oral gavage | 0.6 mg/kg, 24 h | [89] |
 | Female C57BL/6 mice | Oral gavage | 0.5 mg/kg, 24 h | [90] |
 | Female Wistar rats | Oral gavage | 0.4 mg/kg/day, 28 days | [91] |
 | Female SD rats | Oral gavage | 0.2 mg/kg/day, 28 days | [92] |
Nephrotoxicity | Female Wistar rats | Oral gavage | 0.2Â mg/kg/day, 28 days | [95] |
 | Male SD rats | Intraperitoneal injection | 1 mg/kg, 48 h | |
 | Female Wistar rats | Oral gavage | 0.5 mg/kg/day, 28 days | [98] |
Reproductive toxicity | Male SD rats | Oral gavage | 0.1Â mg/kg/day, 56 days | [99] |
 | Male mice | Intraperitoneal injection | 0.06 mg/kg/day, 14 days | [100] |
 | Male C57BL/6 mice | Oral gavage | 0.125 mg/kg/day, 15 days | [101] |
 | Female NIH mice | Oral gavage | 0.025 mg/kg/day, 50 days | [105] |
Cardiotoxicity | Male rats | Oral gavage | 0.1Â mg/kg/day, 14 days | [106] |
 | Male BALB/C mice | Intravenous injection | 1.2 mg/kg, 24 h | |
Splenic toxicity | Female SD rats | Oral gavage | 0.4Â mg/kg/day, 28 days | [93] |
 | Male SD rats | Oral gavage | 1.2 mg/kg, 24 h | [109] |
Lung toxicity | Male SD rats | Oral gavage | 1.2Â mg/kg, 24Â h | [109] |
Gastrointestinal toxicity | SD rats | Oral gavage | 1.0Â mg/kg, 1Â h | [110] |
Skin irritation | New Zealand rabbits | Transdermal administration | 0.025 %, 7 days | [111] |