Fig. 4

BHD reduces renal fibrotic and inflammatory factors in STZ-induced diabetic mice. A Western blot and quantitative analysis. BHD reduced the expression of fibronectin (FN), collagen I (Col I), interleukin-1β (IL-1β) and TNF-α compared to that in DM. DM, diabetes mellitus. Irbesartan (IRB) was taken as a positive control. Data represent the means  ±  SEM for groups of six animals. *P  <  0.05, **P  <  0.01, ***P  <  0.001 versus normal mice. ^#P  <  0.05, ^##P  <  0.01, ^###P  <  0.001 versus DM mice