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Fig. 11 | Chinese Medicine

Fig. 11

From: A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation

Fig. 11

Anti-PC effect of CKI and core targets verification in panc-1 cells. A Dose-inhibition curves of CKI at 24 h, 48 h and 72 h. IC50 = 3.38 ± 1.40 mg mL−1 (24 h); IC50 = 2.20 ± 0.54 mg mL−1 (48 h); IC50 = 1.84 ± 0.38 mg mL−1 (72 h). B, C The proliferation of panc-1 cells was detected by EdU incorporation assay, and observed by confocal microscopy. 10 μM EdU concentration. 2 h labelling time. D The relative mRNA expression of core targets was measured by RT-qPCR after CKI intervention. Data were presented as mean ± SD. n = 3. *P < 0.05; **P < 0.01

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