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Fig. 4 | Chinese Medicine

Fig. 4

From: Shen-Zhi-Ling oral liquid ameliorates cerebral glucose metabolism disorder in early AD via insulin signal transduction pathway in vivo and in vitro

Fig. 4

Effect of SZL cognitive deficits and improved memory abilities in APP/PS1 mice. Simple pattern of MWM (A). The figures represent the first, second, third, and fourth quadrants, respectively. Each quadrant of the inner wall of the MWM has visual signs to help the mice remember route. The platform is in the third quadrant effect of SZL treatment on the moving track (B). The movement trajectories of mice in each group entering water in different quadrants on the fifth day were selected for comparison. The first quadrant is in the upper left corner of the moving track map, and the remaining quadrants are 2, 3, and 4 in the counterclockwise direction. The effect of SZL treatment on mean swimming distances (C), Escape latency (D) times of crossing platform (E) and target quadrant dwelling time (F) in the MWM test. CG: control group, MG: model group, DG: donepezil group, SG: SZL group. All data are presented as means ± SEM (n = 15). *P < 0.05, **P < 0.01 versus Control group, P < 0.05, P < 0.01 versus Model group; One-way ANOVA was used to calculate the p-values. The average swimming distance and escape latency of mice in the Morris Water Maze experiment were repeated measurements, both of which were in line with the spherical test, and a repeated-measures ANOVA was applied

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