Fig. 6

Honokiol attenuates LPS-induced ALI. The male SD rats were intratracheally instilled with LPS (5 mg/kg) to establish the ALI model. Then rats were administrated with HKL (1.25, 2.5, 5 mg/kg) or ML385 (30 mg/kg) intraperitoneally based on the grouped information. Rats were euthanized 24 h after LPS administration. A Flow diagrams of animal experiments, the rats were divided into six groups: control group, LPS group, LPS + HKL (1.25, 2.5, 5 mg/kg) groups, LPS + HKL (2.5 mg/kg) + ML385 (30 mg/kg) group. B Representative images of H&E staining (original magnification × 200). C Lung injury score. D Lung wet/dry weight ratio. Data were analyzed using one-way ANOVA; n = 7–8 rats per group. ^**P < 0.01 compared with the control group; ^#P < 0.05, ^##P < 0.01 compared with LPS group