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Table 5 Anti-DILI effect and mechanism of lignans in natural medicines

From: Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs

No.

Natural medicine

Bioactive components

Mechanisms

The species investigated

References

1

Mangnolia officinalis

Magnolol

Anti-oxidative

Pre-clinical model: Male SD rat (200–250 g)

[162]

2

Schisandra sphenanthera

Lignans extract

Regulation of lipid metabolism

Pre-clinical model: Male C57BL/6 J mice (6 weeks, 18–20 g)

[163]

3

Schisandra sphenanthera

Schisandrol B

Attenuated the increases in ALT and AST activity, inhibiting the activities of CYP2E1 and CYP3A11. Abrogated APAP-induced activation of p53 and p21, and increased expression of liver regeneration and antiapoptotic-related proteins such as cyclin D1 (CCND1), PCNA, and BCL-2

Pre-clinical model: Male C57BL/6 mice (6–8 weeks old, 20–22 g)

[164]

4

Schisandra fructus

Schisandrin A, Schisandrin B, Schisandrin C, Schisandrol A, Schisandrol B, and Schisantherin A

Inhibited the enzymatic activities of three CYP450 isoforms (CYP2E1, CYP1A2, and CYP3A11) related to APAP bioactivation, and further decreased the formation of APAP toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) in mouse microsomal incubation system

Pre-clinical model: Male C57BL/6 mice (6–8 weeks old, 20–22 g)

[165]

5

Schisandra fructus

Schisandrin B

Induction of HSP27 and HSP70

Pre-clinical model: Male Institute of Cancer Research mice (18–22 g)

[166]