From: Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs
No. | Natural medicine | Bioactive components | Mechanisms | The species investigated | References |
---|---|---|---|---|---|
1 | Mangnolia officinalis | Magnolol | Anti-oxidative | Pre-clinical model: Male SD rat (200–250 g) | [162] |
2 | Schisandra sphenanthera | Lignans extract | Regulation of lipid metabolism | Pre-clinical model: Male C57BL/6 J mice (6 weeks, 18–20 g) | [163] |
3 | Schisandra sphenanthera | Schisandrol B | Attenuated the increases in ALT and AST activity, inhibiting the activities of CYP2E1 and CYP3A11. Abrogated APAP-induced activation of p53 and p21, and increased expression of liver regeneration and antiapoptotic-related proteins such as cyclin D1 (CCND1), PCNA, and BCL-2 | Pre-clinical model: Male C57BL/6 mice (6–8 weeks old, 20–22 g) | [164] |
4 | Schisandra fructus | Schisandrin A, Schisandrin B, Schisandrin C, Schisandrol A, Schisandrol B, and Schisantherin A | Inhibited the enzymatic activities of three CYP450 isoforms (CYP2E1, CYP1A2, and CYP3A11) related to APAP bioactivation, and further decreased the formation of APAP toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) in mouse microsomal incubation system | Pre-clinical model: Male C57BL/6 mice (6–8 weeks old, 20–22 g) | [165] |
5 | Schisandra fructus | Schisandrin B | Induction of HSP27 and HSP70 | Pre-clinical model: Male Institute of Cancer Research mice (18–22 g) | [166] |