Table 7 Anti-DILI effect and mechanism of extract for natural medicines
From: Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs
No. | Natural medicine | Bioactive components | Mechanisms | The species investigated | References |
|---|---|---|---|---|---|
1 | Mucuna pruriens | Ethanol extract | Anti-oxidative | Pre-clinical model: adult Wistar albino mice (15–20 g) and rats (100–200 g), either sex | [179] |
2 | Solanum xanthocarpum Fruit | 50% ethanol extract | Anti-inflammatory, hepatoprotective activity | Pre-clinical model: wistar rats (150–170 g) and Swiss albino mice (25–30 g) of either sex | [180] |
3 | Salvia miltiorrhiza | Water extract | maintenance of mitochondrial metabolic activity, CYP2E1 inhibition, reduction of total glutathione depletion | Pre-clinical model: male SD rats (260–280 g) | [181] |
4 | Moringa oleifera Lam | Ethanol extract | Anti-oxidative | Pre-clinical model: male Wistar rats of (180–220 g) | [182] |
5 | Pinellia ternate (Thunb) Breit | Water extract | Anti-oxidative and regulate Nrf2 | Pre-clinical model: male ICR mice (18–22 g) | [183] |
6 | Garcinia mangostana L. | Acetone extract | Activate Nrf2 and inhibit NF-κB signaling pathways | Pre-clinical model: male BALB/c mice (20–30 g) | [175] |
7 | Schisandfa chinensis (Turcz.) Baill | Extract | Active of Nrf2 signal pathway | Pre-clinical model: SPF SD rat, (160–200) g | [184] |
8 | Phyllanthus emblica L. | Extract | Active of Nrf2 /ARE signaling pathway | Pre-clinical model: male C57BL/6 J mice (5–8 weeks old, 18–22 g) | [185] |
9 | Trapa natans | 50% ethanolic extract | Normalizes the altered liver marker enzymes and antioxidant defense status | Pre-clinical model: adult Wistar male rats (140–180 g) | [186] |
10 | Auricularia delicata (Fr.) Henn | Hexane, chloroform, ethyl acetate, and methanol extract | Anti-oxidative | Pre-clinical model: male rat | [187] |