Fig. 6

Western blot analysis of proteins associated with CREB phosphorylation in dorsal hippocampal tissue from non-CRS + saline, CRS + saline, CRS + 10 mg/kg HE, and CRS + 25 mg/kg HE groups. Note, dividing lines represent cropped blots and white spaces represent cropped bands. Blot images (A) and graphical representation of the effects of HE on the expression of neuroplasticity-related proteins including ERK1/2 (B), pERK1/2 (C), AKT (D), and pAKT (E). The expression of target proteins was normalised to the expression of GAPDH. Note, in CRS + 10 mg/kg HE group, there was a significant increase in pERK1/2 protein expression compared with the CRS + saline group and increase in pAKT compared to the non-CRS control group. *p ≤ 0.05