Fig. 8

Graphical representation of the behavioural data in TMZ experimental groups. No significant differences were found in all the behavioural testing for the assessment of anxiety-like behaviour including cage emergence test (A) and novelty suppressed feeding test (B), and depressive-like behaviour including sucrose preference test (C) and tail suspension test (D). Scatter plots of the correlations between the depression-related behavioural tests in the non-TMZ (E) and TMZ experimental groups (F). Notably, in the non-TMZ experimental group, there were significant correlations between the sucrose preference and immobility time in CRS + 10 mg/kg HE, CRS + 25 mg/kg HE, and non + CRS control groups. No correlation was found between the sucrose preference and immobility time in CRS + saline group or all TMZ experimental groups. p ≤ 0.05 considered statistically significant