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Table 2 Distribution of cell subpopulations in TCM syndrome types of CRC

From: Traditional chinese medicine syndromes classification associates with tumor cell and microenvironment heterogeneity in colorectal cancer: a single cell RNA sequencing analysis

Cell types

Cell subpopulations

DES/Numbers (%)

DS/Numbers (%)

ES/Numbers (%)

P*

CRC cell

CEACAM5 + 

55 (37.67)

3 (1.14)

7 (19.76)

 
 

EPCAM + 

0 (0.00)

32 (12.17)

19 (7.51)

 
 

KRT18 + 

1 (0.68)

40 (15.21)

6 (2.37)

 
 

MUC1 + 

1 (0.68)

32 (12.17)

9 (3.56)

 
 

Total

57 (39.04)

107 (40.68)

41 (16.21)

 < 0.001

Immune cell

Myeloid monomacrophage

7 (4.79)

65 (24.71)

24 (9.49)

 
 

DC

10 (6.85)

32 (12.17)

25 (9.88)

 
 

T cell

5 (3.42)

25 (9.51)

11 (4.35)

 
 

B cell

14 (9.59)

5 (1.90)

11 (4.35)

 
 

Macrophage

0 (0.00)

22 (8.37)

21 (8.30)

 
 

Total

36 (24.66)

149 (56.65)

92 (36.36)

 < 0.001

Stem cell

Stem cell

4 (2.74)

5 (1.90)

21 (8.30)

 < 0.005

Fibroblast

EMT Like

11 (7.53)

0 (0.00)

7 (2.77)

 
 

CAFs

0 (0.00)

1 (0.38)

38 (15.02)

 
 

Total

11 (7.53)

1 (0.38)

45 (17.79)

 < 0.001

Enterocyte

Enterocyte

19 (13.01)

0 (0.00)

4 (1.58)

 < 0.001

Goblet cell

Goblet cell

19 (13.01)

1 (0.38)

50 (19.76)

 < 0.001

Total

14

146

263

253

 
  1. *Chi-square test