Fig. 5

GO, KEGG analysis and PPI network. a and b GO enrichment analysis of 2141 overlapping upregulated DEGs and 2038 overlapping downregulated DEGs, including biological process (BP), cellular component (CC) and molecular function (MF). c and d KEGG enrichment analysis of 2141 overlapping upregulated DEGs and 2038 overlapping downregulatesd DEGs. e Interrelationships between genes involved in ERS, apoptosis, and autophagy. f Top 10 major KEGG signalling pathways chord involved in the anti-fibrosis effect of YQRG. Red indicated upregulated DEGs which all were upregulated in the model group relative to YQRG group. and blue indicated downregulated DEGs which all were downregulated in the model group relative to YQRG group. The closer log2FC is to the side, the greater the gene expression difference multiple. The closer log2FC is to the middle, the smaller the gene expression difference multiple. The KEGG pathway information on the enrichment of the first 10 genes with significant differences is shown below. g Visualization of PPI network by Cytoscape. circular nodes represent the major DEGs of YQRG; the size of the DEGs is directly proportional to their degrees in the network