Chinese herbal medicine for functional dyspepsia: a network meta-analysis of prokinetic-controlled randomised trials

Table 10 Classification of interventions based on network meta-analyses on secondary outcomes: domperidone as the comparator

Outcome	Classification of intervention	CHM formula	Standardised mean difference (95% CI)	Surface under the cumulative ranking curve	Certainty of evidence⁺
Alleviation of postprandial fullness	Large beneficial effect^@	Xiao Pi Kuan Wei Decoction	− 2.14 (− 2.76, 0.70)	0.85	Low
	Moderate beneficial effect^#	Modified Zhi Zhu Decoction	− 0.64 (− 2.18, 0.74)	0.45	Low
	Small beneficial effect^†	Modified He Gan Decoction	− 0.39 (− 1.55, 0.54)	0.48	Low
	Small beneficial effect^†	Xiao Pi Tong Jiang Decoction	− 0.34 (− 2.28, 3.30)	0.43	Low
	Trivial to no beneficial effect^‡	He Wei Decoction	− 0.12 (− 1.68, 0.80)	0.45	Very low
Alleviation of early satiety	Large beneficial effect^@	Xiao Pi Kuan Wei Decoction	− 3.90 (− 0.68, − 0.42)	0.92	Low
	Moderate beneficial effect^#	He Wei Decoction	− 0.58 (− 2.69, 2.06)	0.50	Very low
	Trivial to no beneficial effect^‡	Xiao Pi Tong Jiang Decoction	− 0.04 (− 2.12, 1.46)	0.33	Low
Alleviation of epigastric pain	Large beneficial effect^@	Xiao Pi Kuan Wei Decoction	− 1.23 (− 1.66, − 0.29)	0.79	Low
	Moderate beneficial effect^#	He Wei Decoction	− 0.64 (− 1.18, − 0.33)	0.63	Very low
	Moderate beneficial effect^#	Xiao Pi Tong Jiang Decoction	− 0.70 (− 1.44, − 0.35)	0.58	Low

CHM Chinese herbal medicine, CI Confidence interval
^@Large beneficial effect: standardised mean difference ≤ − 0.80
^#Moderate beneficial effect: − 0.80 < standardised mean difference ≤ − 0.50
^†Small beneficial effect: − 0.50 < standardised mean difference ≤ − 0.20
^‡Trivial to no beneficial effect: standardised mean difference > − 0.20
⁺Quality of evidence ratings for comparisons in network meta-analysis on alleviating postprandial fullness, early satiety, epigastric pain, and epigastric burning, respectively. Details refer to Additional file 1: Appendix 7–9
A negative standardised mean difference indicated an effect favouring Chinese herbal medicine, while a positive standardised mean difference indicated an effect favouring prokinetics

ISSN: 1749-8546