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Fig. 4 | Chinese Medicine

Fig. 4

From: Differential action of pro-angiogenic and anti-angiogenic components of Danhong injection in ischemic vascular disease or tumor models

Fig. 4

PAC and AAC affected endothelial cell migration differently. A Representative images of the wound-healing assay in EA.hy926 cells. B Quantitation of the migration distance. PAC or VEGF promoted cell migration while AAC inhibited the cell migration after 12 h. C Representative images of the Oris™ Cell Migration Assay in EA.hy926 cells. D Analysis of ECs-covered area after 12 h incubation or immediately at the stopper removal (pre-migration, 0 h). The same location for all wells was set aside as a detection zone (Green Square), and the cell inhabited area was determined under the indicated conditions. VEGF or PAC promoted cell migration, while AAC inhibited cell migration after 12 h. AAC also reversed the cell migration effect of VEGF, leading to an ultimate inhibition of endothelial cell migration. n = 3. Data are presented as mean ± SD. *P < 0.05, compared with the control group

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