Fig. 7

Identify the critical component of LGZG that inhibit the STING pathway in BMDMs. a–d Concentration of TNFα from the culture media of BMDMs treated with DMXAA and DMXAA co-cultured with different doses of Poriaic acid (a), Cinnamaldehyde (b), Atractylenolide II (c) and Glycyrrhizinate (d). e–h Concentration of IFNβ from the culture media of BMDMs treated with DMXAA and DMXAA co-cultured with different doses of Poriaic acid (e), Cinnamaldehyde (f), Atractylenolide II (g) and Glycyrrhizinate (h). i, j Concentration of TNFα and IFNβ from the culture media of BMDMs treated with DMXAA and DMXAA co-cultured with different doses of mixture of 4 compounds and LGZG. k Immunoblotting analysis of the expression of NF-κB, p NF-κB, TBK1, p-TBK1 and STING. The data are expressed as mean ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.001 vs. DMXAA group