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Fig. 3 | Chinese Medicine

Fig. 3

From: Repurposing a clinically approved prescription Colquhounia root tablet to treat diabetic kidney disease via suppressing PI3K/AKT/NF-kB activation

Fig. 3

Effects of CRT on the histopathological changes of kidney examined by H & E, PAS, PASM, MASSON stainings, and on the expression patterns of the ECM markers in kidney tissues of DKD rats detected by immunohistochemistry. A Representative images of the kidney tissues in different groups examined by H & E staining. Original magnification, × 200, 400. Scale bars represent 100, 50 µm. Red boxes mark the areas with typical pathological changes. B Representative images of the kidney tissues in different groups examined by PAS, PASM, MASSON stainings. Original magnification, × 400. Scale bars represent 50 µm. C Quantitative analyses of PAS, PASM and Masson stainings. D Expression patterns of Collagen I and Fibronectin in the kidney tissues of different groups examined by immunohistochemistry. Original magnification, × 400. Scale bars represent 50 µm. E Semiquantitative data of immunoreactivities of fibronectin and collagen I proteins in the kidney tissues of different groups, respectively. F Expression levels of fibronectin and collagen I proteins in HK-2 cells treated by high glucose detected by ELISA. Data are shown as the mean ± SD. #p < 0.05, ##p < 0.01, ###p < 0.001, comparison with the CON group; *p < 0.05, **p < 0.01, ***p < 0.001, comparison with the DKD group

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