Skip to main content
Fig. 6 | Chinese Medicine

Fig. 6

From: Bioactivities and mechanisms of natural medicines in the management of pulmonary arterial hypertension

Fig. 6

Regulatory mechanisms of microRNAs in PAH. The green arrow indicated the promoted effects of hypoxia or PDGF on microRNAs, yet the red T-shape showed the inhibited effects. The blue box represented the targets or signalling pathways of microRNAs in PAH. The yellow box showed the beneficial effects of microRNAs for the treatment of PAH. PDGF platelet-derived growth factor, MCT monocrotaline, PCNA proliferating cell nuclear antigen, TGF-β transforming growth factor-β, BMPR2 bone morphogenetic protein receptor 2, eIF2α eukaryotic initiation factor 2α, TLR4 toll-like receptor 4, RVSP right ventricular systolic pressure, FOXO3 forkhead box O3, PERP p53 apoptosis effector related to PMP‐22, PPARα peroxisome proliferator-activated receptor-α, PDCD4 programmed cell death protein 4, SPRY2 Sprouty 2, PTBP1 polypyrimidine tract binding protein, PKM2 pyruvate kinase M2

Back to article page