Table 5 Regulatory effects of microRNAs in PAH
MicroRNAs | Environment | Target | Function | Refs |
|---|---|---|---|---|
MicroRNA-629 | Hypoxia-induced PASMCs | FOXO3↓, PERP↓ | PASMCs proliferation↑, migration↑, cell apoptosis↓ | [123] |
MicroRNA-150 | Hypoxia-induced rats | AKT/mTOR↓ | Cardiac output↓, pulmonary fibrosis↓, collagen fibre↓, collagen I↓, α-SMA↓, TGF-β1↓ | [124] |
eIF2α siRNA | PDGF-induced PASMCs | eIF2α↓, LC3B↓ | PASMCs proliferation↓, p62↑, autophagy↓ | [125] |
MicroRNA-23a | Hypoxia-induced PASMCs | BMPR2↓, Smad1↓ | PASMCs proliferation↑, migration↑, PCNA↑, P-smad1↓ | [126] |
MicroRNA-760 | Hypoxia-induced PASMCs | TLR4↓ | Caspase-3↑, Bax/Bcl-2↑, migration↓ | [127] |
MicroRNA-17 | Hypoxia-induced PASMCs | Mitofusin 2↓ | PCNA↑, cleaved caspase-3↓ | [128] |
MicroRNA-21 | Hypoxia-induced PASMCs | PPARα↓, PDCD4↓ | PCNA↑, SPRY2↓, migration↑ | [129] |
MicroRNA‐20a | Hypoxia-induced PASMCs | PRKG1↓ | Proliferation↑, migration↑, PKG↓, α-SMA↑ | [130] |
MicroRNA-210 | Hypoxia-induced PASMCs | E2F3↓ | Apoptosis↓ | [131] |
MicroRNA-4632 | PDGF-induced PASMCs | c-Jun↓ | Apoptosis↑, proliferation↓ | [132] |
MicroRNA-125a-5p | MCT-induced PAH rats | TGF-β1↓, STAT3↓ | IL-6↓, Smad2/3↓, PCNA↓, Bcl-2↓ | [133] |
MicroRNA-124 | Sugen-hypoxia-induced rats | PTBP1↓, PKM2↓ | BMPR2↑, restoring glycolytic | [134] |
MicroRNA-143-3p | Hypoxia-induced mice | TGF-β↓ | Migration↓, RVSP↓, RVH↓ | [135] |
MicroRNA-27a | Hypoxia-induced rats | Smad5↑ | Vimentin↓, CD31↑, α-SMA↓, p-Smad5↑, | [136] |