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Fig. 4 | Chinese Medicine

Fig. 4

From: Red yeast rice ameliorates non-alcoholic fatty liver disease through inhibiting lipid synthesis and NF-κB/NLRP3 inflammasome-mediated hepatic inflammation in mice

Fig. 4

RYR ameliorates hepatic inflammation via inhibiting NF-κB/NLRP3 signaling in HFD-fed mice. A mRNA expressions of NLRP3, IL-1β and IL-18. B Immunoblot analysis of TLR4/NF-κB signaling in the liver, including TLR4, MYD88, p-IKKα/β, IKKα, IKKβ, p-IκBα, IκBα, p-p65, and p65. C Hepatic protein expressions of NLRP3, ASC, pro-caspase-1, caspase-1, pro-IL-1β and IL-1β. GAPDH was used as a control. D,E The densitometry analysis results of the Immunoblot images of the TLR4/NF-κB and NLRP3 inflammasome signaling. Data shown are individual values with means ± SEM (n = 3). **p < 0.01, vs. control group. ##p < 0.01, vs. HFD-fed group

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