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Fig. 2 | Chinese Medicine

Fig. 2

From: Ginkgo biloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways

Fig. 2

The effect of EGb on cisplatin-induced renal fibrosis in rats. A Representative images (× 400 magnification) of H&E-stained renal tissue samples. B Tubulointerstitial injury indices of rats in the indicated groups. C Representative images (× 400 magnification) of Masson’s trichrome-stained renal tissue samples. D Relative area of tubulointerstitial fibrosis (%) in rats in the indicated groups. E, G Representative images (× 400 magnification) of α-SMA and Col I immunohistochemically stained renal tissue sections. Quantification the protein levels of F α-SMA and H Col I in rat renal tissues. n  = 9. *P  < 0.05 vs. control; #P  < 0.05 vs. cisplatin; &P  < 0.05 vs. cisplatin  +  M-EGb. α-SMA α-smooth muscle actin; Col I type I collagen; L low-dose; M medium-dose; H high-dose; EGb Ginkgo biloba leaf extract

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Chinese Medicine

ISSN: 1749-8546

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