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Fig. 4 | Chinese Medicine

Fig. 4

From: Toddalolactone protects against osteoarthritis by ameliorating chondrocyte inflammation and suppressing osteoclastogenesis

Fig. 4

TOD suppresses RANKL-induced gene expression during osteoclastogenesis in vitro. A mRNA expression of osteoclast marker genes (NFATc1, Trap, Ctr, Ctsk, DC-STAMP, and VATPase D2) were detected by RT-PCR. B Western blotting performed that TOD suppressed the activation of osteoclast related protein (Trap, Ctsk, c-Fos, and NFATc1); GAPDH was used as the loading control. C ImageJ software was used to quantify the density of the western blot bands shown in B. Data represent means ± SD of triplicate independent experiments. *, # indicates p < 0.05, **, ## indicates p < 0.01, ns indicates not significant

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