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Table 3 Novel preparations of mineral drugs and preclinical study

From: Mineral medicine: from traditional drugs to multifunctional delivery systems

Register number Study title Conditions Interventions/drugs Locations
NCT04687176 Frontline oral arsenic trioxide for APL APL Dru: oral arsenic trioxide formulation The University of Hong Kong
NCT03624270 Oral arsenic trioxide for newly diagnosed acute promyelocytic APL Drug: oral arsenic trioxide, all-trans retinoic acid, and ascorbic acid The University of Hong Kong
NCT04689815 Oral arsenic trioxide for nucleophosmin 1 mutated acute myeloid leukemia (AML) AML Drug: oral arsenic trioxide formulation The University of Hong Kong
NCT04634838 Efficacy dressings with copper oxide Pressure ulcer Device: medcu antibacterial wound dressings with copper oxide Loewenstein Rehabilitation Center ra'anana, Israel
NCT01565798 Efficacy of copper to reduce acquisition of microbes and healthcare-acquired infections Healthcare-acquired infection Other: copper-alloy surfaced patient care objects Medical University of South Carolina
NCT01678612 Efficacy of copper in reducing health-acquired infections in a pediatric intensive care unit Nosocomial infections Copper-alloy surfaced objects Hospital Roberto del Rio, Santiago, Chile
NCT03323346 Phase II trial of disulfiram with copper in metastatic breast cancer Breast neoplasm female Drug: disulfiram University hospital Olomouc, Olomouc, Czechia
NCT03284749 Effect of copper on the healing of obstetric wounds Cesarean section and infection Other: copper impregnated wound dressing, and normal wound dressing Croydon health services NHS trust
NCT04511468 Zinc, chromium, vitamin C, and copper combination supplement for prediabetes progression Prediabetes Dietary supplement: zinc, chromium, vitamin C, and copper supplementation, and placebo Human Nutrition Research Center
NCT01777919 Disulfiram/copper combination in the treatment of newly diagnosed glioblastoma multiform Glioblastoma multiforme Temozolomide, disulfiram, copper Olympion medical Center, Patras, Greece
NCT00608946 Treatment with copper in patients with mild Alzheimer’s dementia Alzheimer’s disease Dietary supplement: copper  
NCT03736109 Role of a copper-albumin complex in the treatment of knee osteoarthritis in human Osteo arthritis knee Genetic: soluble and genetic biomarkers measurements  
NCT02715609 Disulfiram/copper with concurrent radiation therapy and temozolomide in patients with newly diagnosed glioblastoma Glioblastoma multiforme Drug: disulfiram, and copper gluconate Washington University school of medicine, Saint Louis, Missouri, United States
NCT01017315 Efficacy of baby talcum in the prevention of pruritus assosiated with cast Fracture distal radius Drug: baby talcum Prince of Songkhla university
NCT04792970 Randomized controlled trial of talc instillation in addition to daily drainage through a tunneled pleural catheter to improve rates of outpatient pleurodesis in patients with malignant pleural Malignant pleural effusion Drug: talc Duke University Medical center, Durham, North Carolina, United States
NCT00789087 Talc pleurodesis in patients with recurrent malignant pleural effusion Recurrent malignant pleural effusion Procedure: video thoracoscopic talc poudrage, and talc slurry through a chest tube University of são Paulo medical school
NCT03635138 Effect of the incoportation of copper and zinc nanoparticles into dental adhesives Caries, dental Other: metal nanoparticles (Zn and Cu), and dental adhesive pure Eduardo Fernández G, Santiago, Metropolitana
NCT04775238 Effect of metallic nanoparticles on nosocomial bacteria Nosocomial infections Other: silver nanoparticles, and copper nanoparticles Faculty of medicine-sohag University, Sohag, Egypt
NCT02200978 A study for improving the outcome of childhood acute promyeloid leukemia Childhood acute promyelocytic leukemia Drug: indigo naturalis formula, and ATO, ATRA (and 5 more…) The first affiliated hospital of Sun Yat-Sen University
NCT04489706 Arsenic trioxide in recurrent and metastatic ovarian cancer and endometrial cancer with P53 mutation Ovarian cancer Drug: arsenic trioxide for injection Shanghai Jiaotong university school of medicine affliated ruijin hospital
NCT02966301 Treatment of chronic graft versus host disease with arsenic trioxide Chronic graft-versus-host disease Drug: arsenic trioxide injectable solution CHU de caen-institut d'Hématologie de basse normandie
NCT01470248 Study of arsenic trioxide in small cell lung cancer Lung cancer Drug: arsenic trioxide Emory University Winship Cancer institute
NCT01791894 Arsenic trioxide in treating patients with basal cell carcinoma Basal cell carcinoma of the skin Drug: arsenic trioxide Stanford university medical center
NCT03751917 Long-term safety study of arsenic trioxide in newly diagnosed, low-to-intermediate risk acute promyelocytic leukemia Acute promyelocytic leukemia Drug: Arsenic Trioxide Aon Ss. Antonio E Biagio E C. Arrigo-Alessandria-soc ematologia,Alessandria, Italy
NCT00009867 Arsenic trioxide in treating patients with urothelial cancer Recurrent transitional cell cancer of the renal pelvis and ureter Drug: arsenic trioxide Cancer and leukemia group B
NCT00024258 Arsenic trioxide in treating patients with advanced neuroblastoma or other childhood solid tumors Brain and central nervous system tumors Drug: arsenic trioxide Memorial Sloan-Kettering Cancer Center, New York
NCT00008697 Arsenic trioxide in treating patients with refractory or recurrent acute promyelocytic leukemia Leukemia Drug: arsenic trioxide Washington university school of medicine
NCT00045565 Arsenic trioxide plus radiation therapy in treating patients with newly diagnosed malignant glioma Adult giant cell glioblastoma Drug: arsenic trioxide New approaches to brain tumor therapy consortium, Baltimore
NCT00517712 Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia Acute promyelocytic leukemia Drug: single-agent arsenic trioxide Kidwai memorial institute of oncology, India
NCT00053222 Arsenic trioxide in treating patients with pancreatic cancer that has not responded to gemcitabine Pancreatic cancer Drug: arsenic trioxide Decatur memorial hospital cancer care institute, Decatur, Illinois, United States
NCT00193518 Arsenic trioxide in relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma Chronic lymphocytic leukemia Drug: arsenic trioxide Tennessee Oncology, Nashville, Tennessee, United States
NCT00128596 Arsenic trioxide in treating patients with metastatic liver cancer that cannot be removed by surgery Liver cancer Drug: arsenic trioxide UPMC cancer centers, Pittsburgh, Pennsylvania, United States
NCT00003630 Arsenic trioxide in treating patients with advanced solid tumors Unspecified adult solid tumor, protocol-specific Drug: arsenic trioxide Memorial Sloan-Kettering cancer center, New York
NCT00075426 Arsenic trioxide in treating patients with locally advanced or metastatic non-small cell lung cancer Lung cancer Drug: arsenic trioxide University of texas medical branch
NCT00005069 Arsenic trioxide in treating patients with metastatic kidney cancer Kidney cancer Drug: arsenic trioxide Memorial Sloan-Kettering cancer center New York
NCT00005040 Arsenic trioxide in treating patients with relapsed or refractory non-Hodgkin's lymphoma Lymphoma Drug: arsenic trioxide Memorial Sloan-Kettering cancer center New York
NCT00036842 Arsenic trioxide in treating men with germ cell cancer Extragonadal germ cell tumor testicular germ cell tumor Drug: arsenic trioxide MBCCOP-Gulf coast mobile, Alabama, United States
NCT03503864 Phase II study of combined chemotherapy with arsenic trioxide in stage 4/M neuroblastoma Neuroblastoma Drug: arsenic trioxide Sun Yat-sen memorial hospital, Sun Yat-sen University
NCT04869475 Arsenic trioxide in refractory solid tumors with rescuable p53 mutation Refractory solid tumors Drug: arsenic trioxide Department of Oncology, Ruijin hospital
NCT00621023 Cephalon decitabine, arsenic trioxide, and ascorbic acid for myelodysplastic syndrome Myelodysplastic syndrome Drug: decitabine, arsenic trioxide, and ascorbic acid Duke university medical center