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Fig. 4 | Chinese Medicine

Fig. 4

From: Cucurbitacin E inhibits cellular proliferation and induces apoptosis in melanoma by suppressing HSDL2 expression

Fig. 4

HSDL2 promotes melanoma through the ERK and AKT signalling pathways. A375 cells were infected with shCtrl or shHSDL2 lentivirus. A Phosphorylation of 17 signalling proteins was analysed with the PathScan Stress and Apoptosis Signaling Antibody Array, and the image pixel intensity ratio of signalling molecules is shown. B HSDL2 was overexpressed in A375 cells, and the ERK and AKT signalling pathways were determined by western blotting. C HSDL2 was silenced in A375 cells, and the ERK and AKT signalling pathways were examined by western blotting. Data represent one of three independent experiments. **Pā€‰<ā€‰0.01, compared with the control group

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