Fig. 8

CuE inhibits the ERK and AKT signalling pathways by downregulating HSDL2. A375 cells were treated with CuE for 24 h, and the phosphorylation levels of ERK and AKT were determined by western blotting (A). A375 cells with or without HSDL2 overexpression were treated with CuE, and the phosphorylation levels of ERK and AKT were determined by western blotting (B). Data represent one of three independent experiments