Table 3 The results of molecular docking studies of five main ingredients in the active sites of nine proteins performed using AutoDock
From: Cinnamomi Ramulus inhibits the growth of colon cancer cells via Akt/ERK signaling pathways
Proteins | Ligands | ||||
|---|---|---|---|---|---|
Cinnamic acid | 2-Hydroxycinnamic acid | Protocatechuic acid | Catechinic acid | Taxifolin | |
PRKCA | − 5.47 | − 5.83 | − 6.00 | − 7.44 | − 7.55 |
HSP90AB1 | − 7.33 | − 4.58 | − 6.88 | − 6.27 | − 9.17 |
APP | − 5.68 | − 5.61 | − 5.09 | − 7.52 | − 8.04 |
RELA | − 7.09 | − 6.72 | − 6.52 | − 7.10 | − 7.05 |
JUN | − 4.20 | − 4.66 | − 3.98 | − 4.71 | − 5.21 |
MDM2 | − 5.49 | − 5.53 | − 5.13 | − 6.71 | − 6.83 |
PRKACA | − 7.09 | − 6.81 | − 6.00 | − 7.93 | − 8.19 |
HSPA1A | − 6.24 | − 5.52 | − 5.39 | − 7.56 | − 9.25 |
PARP1 | − 6.79 | − 6.62 | − 6.41 | − 8.62 | − 9.05 |