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Fig. 6 | Chinese Medicine

Fig. 6

From: α-Mangostin inhibits LPS-induced bone resorption by restricting osteoclastogenesis via NF-κB and MAPK signaling

Fig. 6

α-mangostin prevents LPS‐induced bone loss inhibiting osteoclast activity in a mouse calvarial model. A Representative micro-CT reconstruction images of the calvarial each group. Scale bars = 1 mm. B Quantitative analysis of the bone volume against tissue volume (BV/TV, %) and the percentage of porosity (%) was performed using the micro‐CT data, N = 5. C Representative images of H&E staining of calvarial bone sections from sham, vehicle, and 2 µM α-mangostin-treated groups. Scale bars = 200 µm. D Histomorphometric analysis of the BV/TV and erosion area was performed, N = 5. E Representative images of TRAP staining of calvarial bone sections from three groups; cale bar = 50 μm. F Quantitative analysis of the number of TRAP-positive osteoclasts, and the percentage of osteoclast surface per bone surface (OcS/BS, %) were performed, N = 5. *P < 0.05 and **P < 0.01, ***P < 0.001, compared with the mice in the vehicle group

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