Development of software enabling Chinese medicine-based precision treatment for osteoporosis at the gene and pathway levels

Li, Jinyu; Feng, Guiyu; He, Haoyang; Wang, Haolin; Tang, Jia; Han, Aiqing; Mu, Xiaohong; Zhu, Weifeng

doi:10.1186/s13020-022-00596-6

Table 4 The precise relationships among bioactive ingredients, shared genes, and pathways

From: Development of software enabling Chinese medicine-based precision treatment for osteoporosis at the gene and pathway levels

Molecule name	Gene name	Pathway name	Pathway name	Pathway name	Pathway name	Pathway name	Pathway name	Pathway name	Pathway name
Luteolin	Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor	Human T-cell leukemia virus 1 infection	Kaposi sarcoma-associated herpesvirus infection	Epstein-Barr virus infection	Fluid shear stress and atherosclerosis
Luteolin	Baculoviral IAP repeat-containing 5 (surviving)	Platinum drug resistance	Hepatitis B	Chemical carcinogenesis—receptor activation
Luteolin	Cyclin B1	Cell cycle	p53 signaling pathway	Cellular senescence	Progesterone-mediated oocyte maturation
Luteolin	Topoisomerase (DNA) II alpha 170 kda	Platinum drug resistance
Beta-sitosterol	Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	Ovarian steroidogenesis	Leishmaniasis	Human cytomegalovirus infection	Human papillomavirus infection	Kaposi sarcoma-associated herpesvirus infection	Chemical carcinogenesis—DNA adducts	Small cell lung cancer
Beta-sitosterol	Protein kinase, camp-dependent, catalytic, alpha	Ovarian steroidogenesis	Progesterone-mediated oocyte maturation	Cushing syndrome	Human cytomegalovirus infection	Human papillomavirus infection	Human T-cell leukemia virus 1 infection	Viral carcinogenesis	Chemical carcinogenesis—receptor activation
Kaempferol	Nitric oxide synthase 2	Leishmaniasis	Small cell lung cancer
Kaempferol	Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	Ovarian steroidogenesis	Leishmaniasis	Human cytomegalovirus infection	Human papillomavirus infection	Kaposi sarcoma-associated herpesvirus infection	Chemical carcinogenesis—DNA adducts	Small cell lung cancer
Kaempferol	Protein kinase, camp-dependent, catalytic, alpha	Ovarian steroidogenesis	Progesterone-mediated oocyte maturation	Cushing syndrome	Human cytomegalovirus infection	Human papillomavirus infection	Human T-cell leukemia virus 1 infection	Viral carcinogenesis	Chemical carcinogenesis—receptor activation
Kaempferol	Topoisomerase (DNA) II alpha 170 kda	Platinum drug resistance
Kaempferol	Cyclin-dependent kinase 1	Cell cycle	p53 signaling pathway	Cellular senescence	Progesterone-mediated oocyte maturation	Viral carcinogenesis
Kaempferol	Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor	Human T-cell leukemia virus 1 infection	Kaposi sarcoma-associated herpesvirus infection	Epstein-Barr virus infection	Fluid shear stress and atherosclerosis
Kaempferol	Aryl hydrocarbon receptor	Cushing syndrome	Chemical carcinogenesis—receptor activation	Chemical carcinogenesis—reactive oxygen species
Kaempferol	Glutathione S-transferase M1	Platinum drug resistance	Chemical carcinogenesis—DNA adducts	Chemical carcinogenesis—receptor activation	Chemical carcinogenesis—reactive oxygen species	Fluid shear stress and atherosclerosis
Kaempferol	Glutathione S-transferase M2	Platinum drug resistance	Chemical carcinogenesis—DNA adducts	Chemical carcinogenesis—receptor activation	Chemical carcinogenesis—reactive oxygen species	Fluid shear stress and atherosclerosis
Stigmasterol	Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	Ovarian steroidogenesis	Leishmaniasis	Human cytomegalovirus infection	Human papillomavirus infection	Kaposi sarcoma-associated herpesvirus infection	Chemical carcinogenesis—DNA adducts	Small cell lung cancer
Stigmasterol	Protein kinase, camp-dependent, catalytic, alpha	Ovarian steroidogenesis	Progesterone-mediated oocyte maturation	Cushing syndrome	Human cytomegalovirus infection	Human papillomavirus infection	Human T-cell leukemia virus 1 infection	Viral carcinogenesis	Chemical carcinogenesis—receptor activation
(+)-Catechin	Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	Ovarian steroidogenesis	Leishmaniasis	Human cytomegalovirus infection	Human papillomavirus infection	Kaposi sarcoma-associated herpesvirus infection	Chemical carcinogenesis—DNA adducts	Small cell lung cancer
(+)-Catechin	Protein kinase, camp-dependent, catalytic, alpha	Ovarian steroidogenesis	Progesterone-mediated oocyte maturation	Cushing syndrome	Human cytomegalovirus infection	Human papillomavirus infection	Human T-cell leukemia virus 1 infection	Viral carcinogenesis	Chemical carcinogenesis—receptor activation
Digallate	Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	Ovarian steroidogenesis	Leishmaniasis	Human cytomegalovirus infection	Human papillomavirus infection	Kaposi sarcoma-associated herpesvirus infection	Chemical carcinogenesis—DNA adducts	Small cell lung cancer
(2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one	Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	Ovarian steroidogenesis	Leishmaniasis	Human cytomegalovirus infection	Human papillomavirus infection	Kaposi sarcoma-associated herpesvirus infection	Chemical carcinogenesis—DNA adducts	Small cell lung cancer
Aureusidin	Nitric oxide synthase 2	Leishmaniasis	Small cell lung cancer

Molecule name the name of bioactive ingredient

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