Skip to main content

Table 4 The precise relationships among bioactive ingredients, shared genes, and pathways

From: Development of software enabling Chinese medicine-based precision treatment for osteoporosis at the gene and pathway levels

Molecule name Gene name Pathway name Pathway name Pathway name Pathway name Pathway name Pathway name Pathway name Pathway name
Luteolin Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Fluid shear stress and atherosclerosis     
Luteolin Baculoviral IAP repeat-containing 5 (surviving) Platinum drug resistance Hepatitis B Chemical carcinogenesis—receptor activation      
Luteolin Cyclin B1 Cell cycle p53 signaling pathway Cellular senescence Progesterone-mediated oocyte maturation     
Luteolin Topoisomerase (DNA) II alpha 170 kda Platinum drug resistance        
Beta-sitosterol Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Ovarian steroidogenesis Leishmaniasis Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Chemical carcinogenesis—DNA adducts Small cell lung cancer  
Beta-sitosterol Protein kinase, camp-dependent, catalytic, alpha Ovarian steroidogenesis Progesterone-mediated oocyte maturation Cushing syndrome Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Viral carcinogenesis Chemical carcinogenesis—receptor activation
Kaempferol Nitric oxide synthase 2 Leishmaniasis Small cell lung cancer       
Kaempferol Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Ovarian steroidogenesis Leishmaniasis Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Chemical carcinogenesis—DNA adducts Small cell lung cancer  
Kaempferol Protein kinase, camp-dependent, catalytic, alpha Ovarian steroidogenesis Progesterone-mediated oocyte maturation Cushing syndrome Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Viral carcinogenesis Chemical carcinogenesis—receptor activation
Kaempferol Topoisomerase (DNA) II alpha 170 kda Platinum drug resistance        
Kaempferol Cyclin-dependent kinase 1 Cell cycle p53 signaling pathway Cellular senescence Progesterone-mediated oocyte maturation Viral carcinogenesis    
Kaempferol Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Fluid shear stress and atherosclerosis     
Kaempferol Aryl hydrocarbon receptor Cushing syndrome Chemical carcinogenesis—receptor activation Chemical carcinogenesis—reactive oxygen species      
Kaempferol Glutathione S-transferase M1 Platinum drug resistance Chemical carcinogenesis—DNA adducts Chemical carcinogenesis—receptor activation Chemical carcinogenesis—reactive oxygen species Fluid shear stress and atherosclerosis    
Kaempferol Glutathione S-transferase M2 Platinum drug resistance Chemical carcinogenesis—DNA adducts Chemical carcinogenesis—receptor activation Chemical carcinogenesis—reactive oxygen species Fluid shear stress and atherosclerosis    
Stigmasterol Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Ovarian steroidogenesis Leishmaniasis Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Chemical carcinogenesis—DNA adducts Small cell lung cancer  
Stigmasterol Protein kinase, camp-dependent, catalytic, alpha Ovarian steroidogenesis Progesterone-mediated oocyte maturation Cushing syndrome Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Viral carcinogenesis Chemical carcinogenesis—receptor activation
(+)-Catechin Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Ovarian steroidogenesis Leishmaniasis Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Chemical carcinogenesis—DNA adducts Small cell lung cancer  
(+)-Catechin Protein kinase, camp-dependent, catalytic, alpha Ovarian steroidogenesis Progesterone-mediated oocyte maturation Cushing syndrome Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Viral carcinogenesis Chemical carcinogenesis—receptor activation
Digallate Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Ovarian steroidogenesis Leishmaniasis Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Chemical carcinogenesis—DNA adducts Small cell lung cancer  
(2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Ovarian steroidogenesis Leishmaniasis Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Chemical carcinogenesis—DNA adducts Small cell lung cancer  
Aureusidin Nitric oxide synthase 2 Leishmaniasis Small cell lung cancer       
  1. Molecule name the name of bioactive ingredient