Fig. 10

XLLXF inhibition of tumor growth and VM formation in TNBC xenograft model. a Schematic of tumor implantation and XLLXF treatment. b Tumor size was measured every 7 days from day 8 to day 36 after implanting MDA-MB-231 cells and calculated by length × width × width/2. c, d Picture of the tumor after mice were killed. The size of the tumor was also measured. e Ultrastructure of VM in each group, as shown by TEM. Red arrows indicate VM structures. Original magnifications were 2700× (left) and 6500× (right). f VM detection through CD34-PAS dual staining. Red arrows indicate VM structure with CD34-negative and PAS-positive network-like or vascular lumen structures. Original magnifications were 200×