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Fig. 4 | Chinese Medicine

Fig. 4

From: Toosendanin, a late-stage autophagy inhibitor, sensitizes triple-negative breast cancer to irinotecan chemotherapy

Fig. 4

SN-38 induced autophagy in TNBC. A Western blot analysis of LC3-II and SQSTM1 levels in MDA-MB-231 cells treated with the indicated concentrations (0.01–1 μM) of SN-38 for 24 h. B Cells were transfected with a tandem fluorescent-tagged LC3 (tfLC3) and exposed to SN-38 (0.1 μM) or DMSO treatment. The co-localization of GFP-LC3 and RFP-LC3 puncta was examined by confocal microscope and was counted at least 20 cells. Scale bars: 10 μm. The results are the mean ± SD values obtained from three independent experiments (*p < 0.05, **p < 0.01, ***p < 0.001 vs. CTL)

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Chinese Medicine

ISSN: 1749-8546

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