Fig. 7

The correlation analysis of altered bacterial genera and pharmacodynamics parameters. A Spearman’s correlation between 18 altered bacterial genera by RF (Aerococcus, Akkermansia, Anaerostipes, Bifidobacterium, Burkholderia-Caballeronia-Paraburkholderia, Coriobacteriaceae UCG-002, Dubosiella, Ileibacterium, Muribaculum, norank_f_Desulfovibrionaceae, norank_f_Flavobacteriaceae, norank_f_norank_0_norank_c_Clostridia, Paludicola, Parabacteroides, Prevotellaceae_UCG-001, Ruminococcus, Ruminococcus_torques_group, Turicibacter) and 4 pharmacodynamics parameters (ALT, AST, Hyp, SR), the color scale represents the spearman r value, with blue and orange indicating positive and negative correlations, respectively, and *p < 0.05, ** p < 0.01, *** p < 0.001. Correlations of Bifidobacterium abundance with B ALT, C AST, D Hyp and E SR. Correlations of Turicibacter abundance with F ALT, G AST, H Hyp and I SR